By leading the team of teachers and scholars of KPI at various stages of its formation they took the highest responsibility. The progress of the Institute depended on them.
| Victor Lvovovich Kyrpychov, the first Rector, Professor | 1898 - 1902 |  |
| Mykhailo Ivanovych Konovalov, Professor | 1902 - 1904 |  |
| Kostyantyn Oleksiyovych Zvorykin, Professor | 1904 - 1905 |  |
| Mykola Petrovych Chyrvinsky, elected rector, Professor | 1905 - 1906 |  |
| Volodymyr Fedorovych Tymofeev, Professor | 1906 - 1908 |  |
| Kostyantyn Grygorovych Dementyev, Professor | 1908 - 1911 |  |
| Ivan Diomydovych Zhukov, Professor | 1911 - 1917 |  |
| Petro Feofanovich Yerchenko, Professor | 1917 - 1919 |  |
| Georhiy Georgiyovych De-Metz, Professor | 1919 - 1920 |  |
| Oleksa Yakovych Stupin, i/c Rector, Professor | 1919 - 1920 |  |
| Sergiy Feofanovich Veselovsky, Professor | 1920 - 1921 |  |
| Ivan Antonovich Kukharenko, Professor | 03.1921 - 12.1921 |  |
| Victorin Flavianovych Bobrov, Professor | 1921 - 1929 |  |
| Dmytro Fedorovich Melnykov, Professor | 1929 - 1930 |  |
| Mikola Pylypovych Efimov, Professor | 1934 - 1936 |  |
| Pavlo Grygorovych Zhikharev, Professor | 12.1936-08.1937 | |
| Mykola Pylypovych Shpylko , Professor | 1937-1941 |  |
| Oleksandr Sergiyovych Plygunov, Professor | 1944-1952, 1955-1971 |  |
| Vitaliy Nykyforovych Hrydnyev, academician of Academy of Sciences of Ukrainian SSR | 1952 - 1955 |  |
| Ivan Trofyhymovych Shvets , academician of Academy of Sciences of Ukrainian SSR | 09.1955-12.1955 |  |
| Grigoriy Ivanovych Denisenko, corresponding member of Academy of Sciences of Ukrainian SSR | 1971 - 1987 |  |
| Petro Myhaylovych Talanchuk, Professor | 1987 - 1992 |  |
| Mykhailo Zakharovych Zgurovsky, academician of Academy of Sciences of Ukrainian SSR | 1992 - |  |